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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

Treat it as historical in vitro data rather than in-human evidence, the original study used cultured cells, not human subjects [16][17]

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Ocul Immunol Inflamm 28(6):888897 Muntz A et al (2021) Randomized trial of topical periocular castor oil treatment for blepharitis