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Reducing the risk of metabolic diseases: Inhibiting NNMT may counteract the adverse metabolic changes associated with obesity, such as fatty liver disease

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Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner