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Ascorbic acid is necessary for collagen production, so combining THD-ascorbate with stabilized l-ascorbic acid increases cellular activity, thus increasing collagen output

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Important Note on the Evidence Base Important note on the evidence base: The clinical evidence on the IGF-1 axis derives largely from trials of recombinant human IGF-1 (rhIGF-1, sold as mecasermin / Increlex), which is FDA-approved for severe primary IGF-1 deficiency in pediatric patients

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