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Why independent testing
The carrier vehicle matters enormously here: lipid-based formulations that match skin's own fatty acid profile penetrate more effectively than water-based serums
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Furthermore, although the arachnoid epithelium is not a site for CSF production, it expresses claudin 11 together with efflux transporters such as P-glycoprotein, which can influence the penetration of any pharmacological molecules into the brain [166]
The authors thank the MalDA Consortium (PI: Elizabeth Winzeler) and the Medicines for Malaria Venture for their support
2.5 Quantification of oxidative phosphorylation and glycolysis The Seahorse XF96 Extracellular Flux Analyzer (Seahorse Bioscience, North Billerica, MA, United States) was utilized to measure real-time integrated cellular oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) as previously outlined ( 2.6 Western blotting (WB), real-time quantitative PCR (RT-qPCR) and reactive oxygen species (ROS) analysis WB analysis, RT-qPCR, and ROS analysis were performed as previously described (Supplementary Table S1
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