It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026
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Rockville, MD: US Department of Heath, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration
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Research has also reported increased MPO in MDD (33), neurodegenerative disorders including Alzheimer's Disease (74), and preclinical PTSD (32)