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Elevated tryptophan and reduced kynurenine levels were confirmed in these patients, disrupting serotonin and melatonin pathways and contributing to ME/CFS symptoms

Data in A L were analyzed using 2-way ANOVA with Benjamini, Krieger, and Yekutieli post hoc test (FDR = 0.05) to compare individual time points

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Vitamin B12 is known to support emotional well-being by balancing neurotransmitters and helping to reduce stress and anxiety

A molecular medicine report suggests that TMAO promotes p65 NF-B subunit phosphorylation when stimulating macrophages, while hydrogen sulfide inhibits this process by upregulating silent information regulator 1 (SIRT1) (a negative regulator of NF-B) (109)