Both supplements are considered safe for most people
Endocrinologist & Clinical Researcher 7/12 patients reported relief lasting 6+ months from a single injection
Fortified tortillas made from masa produced through the traditional nixtamalization and wet-milling process, where folic acid was added to nixtamal before milling, contained 15%, 33%, and, in one study, even 80% less folic acid compared to the folic acid amount added to nixtamal (theoretical fortified level)
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That is why the article pairs berberine with modest weight change while placing GLP-1 agonists in a substantially higher range
Int J Mol Sci (2020) 21(6):2232