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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

Multivariate analysis of NMR data The bucketing pre-processing procedure was applied on the CMPG spectra, covering the range 10.00.5 ppm, with the exclusion of the spectral region between 5.00-4.7 ppm (containing the residual peak from the suppressed water resonance) obtaining 475 buckets