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Saxenda also positively influences insulin response and post-meal glucose control

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in healthy human volunteers, the eyes open state had correlated higher FCD, ALFF, whole-brain correlation, and glucose uptake than the eyes closed state [27] and awake mice had higher FCD [59], blood flow, and oxygen metabolism [60] than mice under dexmedetomidine anesthesia

doi: 10.1038/ijo.2011.158 [DOI] [PMC free article] [PubMed] [Google Scholar] 240

This prevents overlapping receptor activation that could intensify side effects beyond what either drug would produce alone

In the clinical trials so far, blood sugar effects have been manageable (retatrutide actually improved blood sugar in diabetic patients), and muscle loss has been proportional to weight loss