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Conflicts of interest The authors declare no conflicts of interest

( A ) Resmetirom, a synthetic, liver-targeted, selective thyroid-hormone-receptor- (THR-) agonist, consists of a tri-substituted benzyl ether core in which (i) two iodine atoms present in T3 are replaced by polar, non-halogen substituents (a trifluoromethyl group and a cyano group), and (ii) the hydrophobic phenolic ring of T3 is replaced by a 3,5-dichloro-4-(4-cyano)phenyl moiety

However, clinical evidence for standalone muscle or fat changes is modest

For every 1% reduction in weight , there was a 3.1% lower risk of discontinuation for those with type 2 diabetes and 3.3% for those without

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By activating GLP-1 receptors, it decreases appetite, enhances satiety, and slows gastric emptying, allowing you to stick to low-calorie diets for extended periods without persistent hunger pangs