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doi: 10.3389/fmicb.2019.00616 16 CamejoD.Guzmn-Cedeo.MorenoA
MOTS-c activates AMPK pathways that improve GLUT4 glucose transport, restoring cellular glucose uptake without the GI side effects of metformin.5 For adults managing prediabetes or metabolic syndrome, this is clinically significant
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Acta Diabetol 62 , 731742 (2025)
Recent retrospective evidence has underlined the possibility of preventing psoriatic arthritis (PsA) onset in patients suffering from psoriasis (PsO) by using systemic treatments , particularly biologics [1, 2]
The intravenously administered macrocylic peptidomimetic molecule ulimorelin, enhanced gastric emptying, and was subsequently mainly studied in critical care patients, with lack of differentiation from metoclopramide ( Motilin Motilin is released from M-cells situated in the proximal duodenum during the fasted state, is a stimulus for strong antral contractions and has a hunger signaling function ( In patients with FD and delayed gastric emptying, motilin plasma levels did not display the normal fluctuations during the interdigestive state and gastric phase III contractions were absent ( Several macrolide antibiotics such as erythromycin and azithromycin have motilin receptor agonistic effects, and have a stimulatory effect on gastric emptying rate ( Camicinal is a novel small molecule motilin receptor agonist with short half-life, which was shown to induce gastric phase III contractions during the fasting state and dose-dependently enhance gastric emptying rate ( Cholecystokinin (CCK) CCK is a brain-gut peptide released from I-cells in the upper small intestine upon food intake, especially after meals containing high fat or protein amounts ( H
