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The RNA-seq data of KRT32 overexpressing Ker-CT cell lines, and FFPE samples from 6 PRP with KRT32 mutations in this study have been deposited in the Genome Sequence Archive (GSA) for Human database under accession code HRA006924 and HRA006901 respectively

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GTPs binding and cAMP generation Methods for these assays have been previously described 16

Glutathione injections are not recommended for women who are pregnant or breastfeeding, as the effects have not been thoroughly studied in these populations