immediate labs if new medications are added or symptoms develop If ALT/AST rise above 2x upper limit of normal: Hold both agents, investigate, and reintroduce one at a time after normalization This schedule is conservative
By Administering Glutathione Orally or Intravenously Intravenous glutathione is applied in cases of severe glutathione deficiency, such as cancer treatment and HIV/AIDS treatment, or in individuals who cannot produce adequate glutathione due to genetic mutations or other reasons
Methods Enzymol 252:3853 Ulusu NN, Tandogan B (2007) Purification and kinetic properties of glutathione reductase from bovine liver
FDA has separately warned about injectable NAD+ and glutathione quality FDA has received adverse-event reports after NAD+ injectable drugs, including severe chills, shaking, vomiting, and fatigue consistent with excessive endotoxin exposure
A predisposing condition is bile stasis due to obstruction of the bile duct
The copper oxidizes the vitamin C, neutralizing its antioxidant capacity
