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JNMA J Nepal Med Assoc 2022

10.1038/s41598-020-58566-7 87 LiM.KeJ.GuoS.WuY.BianY.ShanL.et al (2021)

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For example, a type of self-assembled intertwined DNA-RNA nanocapsule (iDR-NCs) can efficiently deliver synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants as well as tumor-specific peptide neoantigens to antigen-presenting cells (APCs) in lymph nodes, which induced neoantigen-specific peripheral CD8 + T cell frequency is 8 times higher than that of CpG alone, inducing T cell memory and significantly inhibiting tumor progression (164)