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In the cardiovascular system, GLP-1R is known to exist not only on cardiomyocytes and endothelial cells, but also in the autonomic nervous system, Figure 3 suggests that GLP-1R may have direct and indirect effects on the heart and blood vessels

To harness these biological effects, scientists developed GLP-1 receptor agonists (GLP-1 RAs) drugs that imitate GLP-1 by activating the same receptors