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A 503A pharmacy compounds for individual patients, whereas a 503B outsourcing facility can produce large batches for healthcare facilities and must follow stricter Current Good Manufacturing Practices (cGMPs)

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The effects of nutlin-3 were dose-dependent, with increasing concentrations of this inhibitor resulting in greater p53 stabilization, which correlated with increased induction of the p53 target genes CDKN1A and HDM2 and greater suppression of erastin2-induced ferroptosis (Fig S1AD)