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Further high-resolution 3D imaging to confirm endosomal GLP-1R localisation to ERMCSs included in situ correlative light and electron microscopy (CLEM) at room temperature to correlate ultrastructural features with positive fluorescent signals for SNAP/FLAG-hGLP-1R, EGFP-VAPB and mitochondria

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These glucagon-like peptide-1 (GLP-1) receptor agonists a type of medicine to help regulate appetite and blood sugar have shown promising results in helping people manage their weight and improve their health

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Among the primary reasons reported for low adherence and persistence, the severity of adverse events was most common [37]

In the OASIS 4 trial, adults taking oral Wegovy 25 mg pill (the highest dose) lost an average of about 13.6% of their body weight after 64 weeks when all participants were included in the analysis