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1 Introduction Moderate elevations in circulating prolactin have been associated with favorable metabolic effects ( The global prevalence of overweight and obesity continues to rise and represents a major public health concern ( Several studies have demonstrated a positive association between serum prolactin levels and body mass index (BMI), suggesting a potential role for hyperprolactinemia in obesity pathophysiology ( 2 Prolactin: biological characteristics 2.1 Structure and secretion regulation Human mature prolactin is a 199-amino-acid polypeptide with an estimated molecular mass of ~23 kDa ( Prolactin-secreting cells (lactotrophs) in the anterior pituitary gland are the primary sources of prolactin synthesis and secretion