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The frequency of lactic acidosis was 4064 per 100,000 patients per year and probably related to renal insufficiency similar to metformin therapy 64

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Particularly, tumor growth under hypoxia or mitochondrial dysfunction relies almost exclusively on this reductive glutamine metabolism for lipid biosynthesis (Metallo et al., 2011)

5.4 Gene therapy: targeting underlying molecular defects Gene therapy in PD aims to: Restore dopamine synthesis: e.g., via delivery of aromatic L-amino acid decarboxylase (AADC)

Gill HS, Denson DD, Burris BA, Prausnitz MR

HSCs are differentiated into common myeloid progenitors (CMPs), which give rise to the entire myeloid lineage [33]