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3841 Arginine is transported into cells where it is a substrate for the enzyme nitric oxide synthase (NOS) that produces nitric oxide (NO)

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Common overlapping side effects include gastrointestinal symptoms (nausea, vomiting, abdominal pain), increased heart rate and blood pressure, and excessive appetite suppression

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A "thrifty" genotype was defined as "being efficient in the intake and/or utilization of food." Thus, during famines, individuals with a "thrifty" genotype would have a survival advantage because they relied on larger, previously stored energy to maintain homeostasis, whereas those without "thrifty" genotypes would be at a disadvantage and less likely to survive (4)

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