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Dual (GCGR/GLP-1R and GIPR/GLP-1R) and triple (GCGR/GIPR/GLP-1R) agonists have led to improvements in lipid metabolism and hepatic steatosis [6, 64,65,66]

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This process can upregulate the expression of steroidogenic genes such as those encoding aromatase and StAR, along with the LHR gene (105, 106)

Patients should contact their provider if they experience signs of hypoglycemia (confusion, sweating, tremor, rapid heartbeat), particularly if taking tirzepatide concurrently with insulin or sulfonylureas, as dose adjustments of these medications may be necessary

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The GSSG/GSH ratio was calculated by dividing the GSSG concentration by the GSH concentration