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It is known that they interact with transcriptional repressor factors, exerting a negative regulatory effect on transcriptional activation of NRF2

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The authors reported that peak citrulline concentration occurred with a 15 g dose (3849 190 mol.l 1 ), which was significantly higher (+ 28.4%) compared to 10 g citrulline (2756 170 mol.l 1 )