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CX3CL1-CX3CR1 is a critical signaling pathway that is disrupted in neurodegenerative conditions and is associated with a strong microglial toxicity (Keren-Shaul et al., 2017)

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The result is inflammation, autoimmunity and chronic disease

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Recently, emerging evidence suggests that SLC1A2 is associated with autoimmune diseases of the central nervous system and peripheral tissues