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Since then, thirteen different companies have tried to crack oral insulin

This means weeks of subtherapeutic dosing during each transition, periods where you are likely not getting adequate appetite suppression or weight loss benefits

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According to publicly disclosed topline results from the Phase 3 EVOKE and EVOKE+ programs data that are currently available only as preliminary announcements and have not yet been fully peer-reviewed or published the trials did not demonstrate clinical efficacy (Athauda et al., 2026)

The FDA hasnt reviewed it

It has taken us, so far, one-third of the time to issue warning letters from the date that the inspection closes to the date of warning letter issuance. 16 The April 2025 reduction in force (RIF) at FDA does not appear to have impacted WLs for FY25