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Intriguingly, studies in rats have correlated the diminution of GLP-1stimulated natriuresis in hypertensive animals with a reduction of GLP-1R expression in the kidney (42, 43)

Additionally, they can modulate macrophages via the Nrf2/HO-1 pathway, inhibiting the dissemination of inflammatory signals

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Original approval was November 2010, with updated formulations (Egrifta SV and Egrifta WR) approved subsequently