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In vitro studies demonstrated that hepatocytes challenged with several kinds of saturated fatty acids or lysophosphatidylcholine (LPC) showed activation of the apoptotic UPR and subsequent cell death [55, 56] (Fig

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The fact, however, that OvSH exists as thiolate nearly throughout the pH scale, explains its wide pH range antioxidant potency compared to conventional thiols such as glutathione (latter is inherently a stronger reducing agent, but it exists mostly in the inactive protonated form at neutral pH and below)

doi: 10.3389/fnmol.2019.00173 63 MostafaG

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