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Meta-analysis was performed using a random-effects approach in case of significant between-study heterogeneity

This combination reduces the efficiency of the folate-related enzyme by about 50% and makes it important to consume plenty of folate-rich foods in the diet

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The GLP-1RA exenatide has been shown to reduce hyperactivation in brain regions associated with appetite and reward in response to food cues in both obese individuals with type 2 diabetes and obese normoglycemic subjects, thereby normalizing neural activation patterns to resemble those observed in lean individuals [48]

Nevertheless, this condition also occurs in asymptomatic individuals, which prevents researchers from definitively determining DAO deficiency as a cause, a consequence, or a nonspecific biomarker of HIT