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Semaglutide (Ozempic, Rybelsus) is the most commonly prescribed

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Don't underestimate the power of past successes (and failures) in developing novel medicines

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The STEP trials for semaglutide and the SURMOUNT trials for tirzepatide both measured outcomes over 6872 weeks, and researchers have documented significant weight regain in patients who discontinue treatment prematurely

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Administration of the horomone leptin to obese animals produced weight loss by decreasing appetite while at the same time increasing the rate of fat metabolism

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His take: medicine is not one-size-fits-all, and the patient-physician relationship needs to come back

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