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89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

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PIONEER 4 is a clinical trial that compares injectable and oral GLP-1s

it concerned highly purified eicosapentaenoic acid (EPA) (icosapent ethyl) which in a dose of 4 g/day demonstrated high efficacy in both primary prevention (in patients with diabetes and other risk factors) and secondary prevention in patients with ASCVD, reducing the primary endpoint of the study by 25% (HR = 0.75

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Longitudinal multi-omics of hostmicrobe dynamics in prediabetes