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First identified in human plasma in the 1970s, this small tripeptide glycyl-L-histidyl-L-lysine, bound to a copper ion has become one of the most extensively referenced compounds in dermal and wound-healing research literature, largely because its copper-binding structure gives it a distinct mechanism from most other peptide sciences on the market

The results indicated that administration of Parkia speciosa extract increased plasma NO levels and decreased systolic blood pressure, along with reduced angiotensin-converting enzyme and NADPH oxidase activities, and lipid peroxidation in the heart (Kamisah et al., 2017)