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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]
@LillyPad #medtwitter #endotwitter pubmed.ncbi.nlm.nih.gov/35985340/ #retatrutide is a novel triple agonist peptide at the glucagon receptor, GIP receptor, and GLP-1 receptor
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Existen dos formas activas principales: GLP-1(7-36) amida con 30 aminocidos (la forma predominante en circulacin) y GLP-1(7-37) con 31 aminocidos
GLP-1 is also secreted from neurons in the caudal brainstem, and it is well-established that, in rodents, central administration of GLP-1 potently reduces food intake
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