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CETP-targeted vaccines have also shown promise in preclinical studies

The KIT gene controls mast cell creation from stem cells in the bone marrow, and mutations in KIT cause excess mast cell proliferation.[ref][ref] A mastocytosis diagnosis is either systemic mastocytosis (affecting the whole body) or cutaneous mastocytosis, which has more skin-related symptoms

Wharton et al., 2025)

Abnormal IGF-1 and GH levels have been proposed to play a key role in obesity [130, 240, 241]

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