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Semaglutide, a GLP-1 receptor agonist, is an effective weight loss treatment used alongside lifestyle changes

Conversely, sacubitril/valsartan has been shown to increase PRA, ANG I and ANG II levels in a canine model of RAAS activation

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1 Because of this possible interaction, the Wegovy pills prescribing information advises monitoring thyroid levels when semaglutide and levothyroxine are taken together

Altman BJ, Stine ZE, Dang CV