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170 Smaller systematic reviews and metaanalyses based on fewer RCTs, reviews, and observational studies also reported that metformin reduced early pregnancy loss, 22 , 172 , 173 late miscarriage, 174 , 175 GDM, 22 , 170 , 172 , 173 , 176 preeclampsia, 22 , 173 PIH, 170 , 171 , 172 macrosomia, 170 and preterm delivery 170 , 172 , 173 , 174 , 177 , 178 in metforminexposed women with PCOS, with increased head circumference in offspring

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