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It achieves higher effective drug concentrations at pulmonary lesions, thereby enhancing therapeutic efficacy, while simultaneously minimizing systemic exposure in off-target organs

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However, GLP-1's very short half-life, arising from cleavage by the enzyme dipeptidyl peptidase 4 (DPP-4) and glomerular filtration by the kidneys, presented challenges for clinical use

Anand JR, Droby GN, Joseph S, Patel U, Zhang XY, Klomp JA, et al

SnCE1 uses all variable regions, i.e., VR-1 located at the N-terminus, VR-2 preceding the first -strand, VR-3 and its far C-terminal residues including the -carboxylate for SUMO1 binding at S1 (Fig