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Measure group scores are then standardized to a common scale, making varying scores comparable
Many patients are surprised to learn they've gained muscle mass while the scale drops, because muscle is denser than fat and weighs more by volume
Occludin, claudin-5, and claudin-8 were found to be downregulated and redistributed, whereas claudin-2 (pore-forming TJ protein) was strongly upregulated
The mechanism: IGF-1 receptor activation in renal tubules increases sodium reabsorption, expanding plasma volume and driving fluid into interstitial spaces
Phenomixs CEO Mark Bagnall spoke with Pharmaceutical Executive about this data and what the impact is on GLP-1 users