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In the human gut, bacteria break down dietary tryptophan, releasing compounds like skatole and indole which give feces their unpleasant aroma

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However, inflammatory responses can cause excessive activation of microglia, impairing their ability to effectively uptake and degrade A [59]

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The implications include altered metabolism of several biomolecules and enzyme systems of well-established pathophysiologic relevance such as vitamins B6, B9 (folate), B12, D3, NO, lipids, amino acids, proteins, DNA, cytochrome P-450 and other enzyme systems, HO, and homocysteine