GLP-1R agonists may exert antidepressant effects by modulating inflammatory processes in the brain Chronic inflammatory processes in the brain associated with excessive activation of microglia and increased production of pro-inflammatory cytokines are one of the key factors leading to the development of depressive symptoms, as patients suffering from this mental illness are very often characterized by elevated levels of tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 beta (IL-1), C-reactive protein (CRP), and interferon-gamma (IFN-) in the cerebrospinal fluid and the blood [59,60,61]
Exposure to Environmental Toxins Pollutants, heavy metals, pesticides, and synthetic chemicals can increase oxidative stress , requiring higher levels of glutathione for detoxification
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Maroon is the author of six books, and (co-)author of 40 book chapters and over 270 published scientific papers
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