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Systemic therapy of plaque-type psoriasis ameliorates endothelial cell function: results of a prospective longitudinal pilot trial

These lipidation and amino acid substitutions solve two fundamental problems with native human amylin: its extremely short plasma half-life (measured in minutes) and its well-documented tendency toward amyloid fibril formation

Corticosteroids degrade collagen and thin the dermis with prolonged use

The preclinical evidence compiled in animal models, however, offers a highly dependable, reproducible dataset demonstrating accelerated soft tissue remodeling, localized capillary formation, and cellular matrix organization

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This became part of the standard management of pernicious anemia until the 1950s