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2 Semaglutide converges these principles: the second residue is replaced by -aminoisobutyric acid (Aib) to avoid DPP-4 degradation, Lys 34 is replaced by Arg 34 , and a C18 fatty acid is linked to Lys 26 via a Glu-2xOEG spacer (Figure 1) providing higher affinity to albumin