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In summary, there remains a lack of clinically relevant data on rhein and emodin, thereby necessitating further exploration into its clinical efficacy as well as appropriate dosing and treatment regimens

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(ref) Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, Ljubanovic D, Coric V, Konjevoda P, Petek M, Rucman R, Turkovic B, Perovic D, Mikus D, Jandrijevic S, Medvidovic M, Tadic T, Romac B, Kos J, Peric J, Kolega Z

For pain management specifically, it excels at promoting tendon and ligament healing, muscle repair and recovery, reduced pain perception, improved joint function, and accelerated healing of soft tissue injuries

risk factors [#1/2] Requisite risk factor is a causative drug : Chronic acetaminophen is the most common cause

Ziegler, D., Behler, M., Schroers-Teuber, M