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Medifast has published company-sponsored research showing meaningful short-term outcomes, and in 2026 the program qualified for medically sanctioned HSA/FSA reimbursement on the strength of that evidence

Persistent numbness or weakness after an injection should always be reviewed by a doctor

It also dropped A1C levels by as much as 1.6 points, making it a solid dual-threat for those managing both blood sugar and body weight

Although results may vary by individual, the effects can last several hours, and regular use may support long-term vitality

Increased blood pressure Though PT-141 does not directly affect blood vessels, a minority of users have experienced a temporary rise in blood pressure

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