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Notably, reduced melatonin levels and disrupted 24-hour melatonin rhythms are frequently observed in individuals with AD dementia [36,37,38,39,40]

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Simulating the effects of in vitro drug treatment, phenylephrine (PE) stimulation was given for 48 hours, and drug treatment was given for 48 hours

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The combined administration of LLP and APS exhibited a superior antidepressant effect compared to the individual administration of polysaccharides