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Mangiola et al., 2016

[72] hypothesized that the enhanced 5,10-methylene-THF pools could result in decreased misincorporation of uracil into DNA, thereby resulting in fewer double strand breaks

alternative contraceptive methods should be considered for 4 weeks after starting treatment and after each dose increase

It flags a history of gastroparesis, severe dehydration, or taking other medications that also delay gastric motility as reasons to inform a provider immediately, because the risk profile differs from ordinary adaptation nausea

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