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Linares, D., Michaud, P., Delort, A

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10.2337/dc09-1203 230 RossatoM.GranzottoM.MacchiV.PorzionatoA.PetrelliL.CalcagnoA.et al (2014)

Both are administered via a weekly injection and shown to produce meaningful weight loss when combined with lifestyle changes

Sulfone-containing 1,3-benzothiazinone derivative as dual cyclooxygenases-2 (COX-2)/tumor necrosis factor-alpha (TNF-) inhibitors To further investigate combined tetrazole-based sulfonamide analogs, a range of tetrazole-bearing compounds were synthesized and evaluated for their in vitro COX inhibitory action, as well as their anti-inflammatory activity by measuring IL-6 and TNF- expression levels (101)