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Given cryo-EM structures of the GLP-1R in complex with G s are stabilised by trapping the nucleotide-free G protein on the ligand-activated receptor, it is not surprising that the G s interactions are similar across the four structures, even when bound by different agonists, nonetheless, the MD simulations revealed potential differences in the dynamics of these interactions

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In addition, the quantity of mitochondria was increased in TAC group, compared to those in Sham group, but the quantity of mitochondria was decreased in TAC + semaglutide group, compared to those in TAC group (Fig

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