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Harris and his teamincluding URochester chemist Tom Driver, the Robert K
In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone
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Consistent with negative feedback by p21 on p53 levels (Broude et al, 2007), induction of p21 FL and p21 N , but not p21 C , decreased basal p53 levels and attenuated p53 stabilization upon nutlin-3 treatment, further validating the function of these proteins (Fig 2E)
Dramatic results are common but not universal