Triple-hormone-receptor agonist retatrutide for obesity: A phase 2 trial. New England Journal of Medicine
BY REGION The GLP-1 agonists market covers North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa
This proactive approach not only enhances the treatment experience but also empowers patients to take an active role in their health management
The development of triple-action peptides, such as Retatrutide, suggests that were moving toward more sophisticated and personalized approaches to metabolic health
Some Retatrutide trial participants achieved weight loss exceeding 27% at the 12mg dose
Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023