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Petucci, C

10.3945/ajcn.112.042457 68

1:46-52 [PMC free article: PMC5747031] [PubMed: 29404432] 206

Pregnancy and lactation Daily iodine requirements are significantly increased in pregnant and breastfeeding women because of (1) the increased thyroid hormone production and transfer to the embryo/fetus in early pregnancy before the fetal thyroid gland becomes functional, (2) iodine transfer to the fetus during late gestation, (3) increased urinary iodine excretion, and (4) iodine transfer to the infant via breast milk (see also The RDA) (14, 21)

In some cases, significant weight loss and energy deficit can lead to functional hypothalamic amenorrhoea, where the brain temporarily reduces signals to the ovaries