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[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders

It tells the brain to slow down hunger

doi: 10.1056/NEJMoa1603827 18

McNeill JM, Choi YC, Cai Y-Y, Guo J, Nadal F, Kagan CR, et al

Further research is necessary to clarify the peptides pharmacology, toxicology, and potential clinical relevance

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